|
(Hyaluronic Acid)
|
||
| (2S,3S,4S,5R,6R)-6-[(2S,3R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | ||
| - |
? | |
| CAS | ||
| PubChem | ||
| ? | ||
| , , , | ||
| -, , | ||
́ ́ (́, ́) , , . , (, .). , . (. Streptococcus). 70 15 , ( ) .[1]
|
|
[]
, (). , , . ( ). ( ) , .[2]
, , , , CD44. CD44.
CD44, , TLR2, TLR4 . - (TLR) .
[]
1950- (Karl Meyer).
-(2--2--D-)-D-, , D- D-N-, β-1,4- β-1,3- (. ).
25 000 . 5 000 20 000 000 . , 3 140 000 .[3]
[]
, -. -: HAS1, HAS2 HAS3. , N-, («») .
[]
[]
[]
, (, , ), , (, .): ; ; ( ) .
[]
[]
« » 1934 . (K. Meyer) . (J. W. Palmer), .[4] . hyalos .
[] .
[]
- Stern R (August 2004). «Hyaluronan catabolism: a new metabolic pathway». Eur J Cell Biol 83 (7): 317-25. PMID 15503855. 2007-06-12.
- Holmes M W A, Bayliss M T, Muir H (1988). «Hyaluronic acid in human articular cartilage. Age-related changes in content and size». Biochem J 250: 435-441. PDF-
- Saari H et al. (1993) Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate. Inflammation 17:403-415.
- K. Meyer and J. W. Palmer (1934). «The polysaccharide of the vitreous humor». J. Biol. Chem. 107: 629-634. PDF-
| : | |
|---|---|
| , | |
| , | (, ) · · |
| , | |
| . : , | |
| : | · · · | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| · | |||||||||||||||
|
|||||||||||||||
|
|||||||||||||||
| · · · · · · | |||||||||||||||
| . , . |