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Glioblastoma (1).jpg
-10 C71.71.
-9 191191
- M9440/3
OMIM 137800 137800
DiseasesDB 29448 29448
eMedicine neuro/147  med/2692med/2692 neuro/147  med/2692med/2692
MeSH D005909 D005909
15-

(. Glioblastoma multiforme, GBM)  , 52 % 20 % . , , 100000 2-3 . [1]

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, , p53, p53 , - , .[2][3]

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: LOH 10q (69%), EGFR (34%), TP53 (31%), p16INK4a (31%) PTEN (24%). TP53 LOH 10q (65% and 63%), . [4]

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  1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P The 2007 WHO Classification of Tumours of the Central Nervous System Acta Neuropathol (2007) 114:97-109. PMID 17618441
    (. BrainLife.org: 2007 ) WHO Classification
  2. Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y (June 2009). «Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model». Cancer Cell 15 (6): 51426. DOI:10.1016/j.ccr.2009.04.001. PMID 19477430.
  3.   .
  4. |Hiroko Ohgaki , Pierre Dessen , Benjamin, Jourde, Sonja Horstmann, Tomofumi Nishikawa, Pier-Luigi Di Patre, Christoph Burkhard, Danielle Schüler, Nicole M. Probst-Hensch, Paulo César Maiorka, Nathalie Baeza, Paola Pisani, Yasuhiro Yonekawa, M. Gazi Yasargil, Urs M. Lütolf, and Paul Kleihues|title= Genetic Pathways to Glioblastoma|October 15, 2010, 70 (20)|http://cancerres.aacrjournals.org/content/64/19/6892.full.pdf+html?sid=d0e2c3c6-b6a6-40cd-9d17-7e588632a25c=}}


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